Is Gene Therapy the Solution to Obesity and Diabetes?
September 3, 2019
By Neozene

This article originally appeared in FierceBiotech and was written by Arlene Weintraub The gene FABP4 is highly active in adipose tissue and known to be a major contributor to obesity and related diseases like type 2 diabetes. Researchers at Hanyang University in Seoul have developed a way to silence the gene using a type of gene-editing technology called CRISPR interference. When the researchers inhibited FABP4 in white adipose tissue—commonly known as the unhealthy white fat—they observed a reduction in lipid storage. Then they tried it in mice that had been fed a

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‘Nano-Immunotherapy’ Halts Glioblastoma in Mice
August 29, 2019
By Neozene

This article originally appeared in FierceBiotech and was written by Arlene Weintraub One of the most difficult challenges in treating the brain cancer glioblastoma is that few drugs can pass through the blood-brain barrier. Scientists at Cedars-Sinai in Los Angeles have developed a system to circumvent this hurdle—one that combines a powerful immuno-oncology drug with a polymer-based delivery vehicle that can cross the blood-brain barrier. The researchers showed that this “nano-immunotherapy” treatment crossed the blood-brain barrier in mouse models of glioblastoma, and that it stopped tumor cells from multiplying. They

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Restoring Neurons to Preserve Memory After Heart Attack or Stroke
August 21, 2019
By Neozene

This article originally appeared in FierceBiotech and was written by Arlene Weintraub People who suffer from heart attacks or strokes face a high risk of memory loss, because when fresh blood stops flowing in the brain, neurons in a region of the hippocampus involved in memory can die. Now, Stanford University researchers are proposing a new strategy for helping the brain recover those brain cells—and it involves controlling the activation of genes that can coax surrounding cells to transform into neurons. The team showed that blocking a particular microRNA in

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