How Gold Nanoparticles Could Improve CRISPR Gene Editing
May 28, 2019
By Neozene

The CRISPR-Cas9 gene editing system has been hailed as a promising solution to a range of genetic diseases, but the technology has proven difficult to deliver into cells. One strategy is to open the cell membrane using an electric shock, but that can accidentally kill the cell. Another is to use viruses as couriers. Problem is, viruses can cause off-target side effects. Scientists at Fred Hutchinson Cancer Research Center are proposing an alternative delivery vehicle: gold. They developed gold nanoparticles that can be packed with all the CRISPR components necessary

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Mount Sinai researchers isolate placental cells that regenerate damaged hearts in mice
May 21, 2019
By Neozene

Back in 2011, researchers at the Icahn School of Medicine at Mount Sinai generated some excitement in the cardiology community when they announced they had used stem cells from placenta to regenerate damaged hearts in pregnant mice. Now, they’ve taken that research a step further, isolating the precise population of cells that have that regenerative ability. The Mount Sinai team discovered that Cdx2 cells in the placenta of mice can migrate through the circulatory system and target heart injuries. Once there, the cells transform into beating heart cells and start the repair

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Stroke drug cocktail normalizes brain fluids, restores movement in mice
May 14, 2019
By Neozene

Adrenergic receptor (AdR) antagonists work by counteracting electrical and chemical disturbances in the brain. New research in mouse models suggests that a cocktail of these drugs may reduce the spread of tissue damage and aid in recovery. Researchers led by the Riken Center for Brain Science in Japan administered AdR blockers to mice following a stroke and observed fluid in the brain, which can accumulate and lead to damaging swelling. They discovered that the drugs normalized fluid exchange and helped level out potassium in the animals’ brains. Mice that received

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